Notes uses the "topmost" database of the replicas in the icon stack on the workspace, when a user tries to open a database. This order easily gets messed up by database/view/doc links i emails etc and other things.
Suddenly the user is on a server 1000 miles away and can not understand Notes is so slow!.
Please have a prioritized server/cluster for user which is ALWAYS used first.
The general setting should be able to be overruled by a pr database setting